Senior Medical Director, Watertown

Senior Medical Director

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About C4 Therapeutics: C4 Therapeutics (C4T) (Nasdaq: CCCC) is a clinical-stage biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of medicines that transforms patients’ lives. C4T is progressing targeted oncology programs through clinical studies and leveraging its TORPEDO platform to efficiently design and optimize small-molecule medicines to address difficult-to-treat diseases. C4T’s degrader medicines are designed to harness the body’s natural protein recycling system to rapidly degrade disease-causing proteins, offering the potential to overcome drug resistance, drug undruggable targets and improve patient outcomes. For more information, please visit .

Job Summary As a Senior Medical Director, reporting to our Chief Medical Officer, you will guide and support clinical programs, bringing together your medical expertise, collaborative mindset, and ability to inspire cross-functional teams. You will shape the clinical development plan for new compounds, co-design and oversee clinical studies, and partner with Program Teams across Research & Development to map the path toward regulatory approval. You’ll work closely with colleagues across all phases of development, lead discussions with academic study investigators, engage with opinion leaders, and represent C4T with Health Authorities. A genuine passion for advancing science, a talent for uniting diverse perspectives, and a shared commitment to improving the lives of patients with cancer will be key to success in this role. Your Role Drive development programs, collaborating with Program Management, Clinical Operations, Regulatory Affairs, and cross-functional teams, collaboratively designing and refining oncology clinical study protocols from first-in-human Phase I through pivotal studies supporting regulatory submissions. Serve as a medical monitor for multiple clinical trials in relapsed refractory multiple myeloma, ensuring high-quality evaluation of clinical and laboratory data, guiding decision-making on recruitment, study conduct and on dose escalation and early clinical signals of activity if appropriate to trial stage. Provide input and leadership in preparing global regulatory filings, including clinical sections of Investigator’s Brochures (IBs), Investigational New Drug (IND) applications, Clinical Trial Applications (CTAs), and New Drug Applications (NDAs). Facilitate regular engagement with academic clinical investigators, support site initiation visits, and lead investigator meetings in a way that fosters collaboration, trust, and shared learning. Partner with Pharmacovigilance to review and interpret clinical data, ensuring accuracy, context, and patient safety. Represent C4T with the scientific community, contribute to publication plans, and build relationships with external experts to inform program strategies. Your Background Required: A M.D. with experience in adult hematological oncology, plus at least two years of clinical development experience in biotechnology or pharmaceutical settings (or equivalent combination of academic and industry experience). Knowledge of drug development from IND through NDA, including experience with companion diagnostics, clinical operations, and pharmacovigilance. Experience designing and delivering early- and late-stage programs, including proactively addressing challenges and aligning teams toward shared outcomes. A flexible contributor who can balance strategic vision with hands-on execution. Skilled communicator who listens actively, adapts to diverse audiences, and builds understanding across teams and stakeholders. C4 Therapeutics is an Equal Opportunity Employer.

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Location:: Watertown
Job Type:: FullTime

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