Ampersand Biomedicines is an innovative, privately held biotechnology company leading the way in developing programmed biologics that only act where they are needed in the body (www.Ampersand.bio). Ampersand was founded in Flagship Pioneering’s venture creation engine, and recently announced progress on the platform, pipeline, partnerships, and financing. With a strong emphasis on innovation, Ampersand cultivates a highly dynamic and entrepreneurial environment.

Check all associated application documentation thoroughly before clicking on the apply button at the bottom of this description. Position Summary: Ampersand is looking for an enthusiastic and motivational leader to head our Protein Sciences team. This individual will lead an established team of protein scientists responsible for the design and engineering of therapeutic biologics. This is an exciting opportunity to lead and grow the Protein Sciences team to your vision while strengthening Ampersand’s platform for designing biologics to support our mission. Level and title will be matched to the depth of experience.

Key Responsibilities

Direct early-stage discovery biologics engineering programs that deploy the Ampersand technology platform.

Guide project leads in the Protein Sciences team to design engineered proteins, monoclonal/bispecific antibodies, and other biologics of interest to the company.

Contribute scientific expertise to strategic decision making and technical innovation within the Protein Sciences group.

Drive program-specific protein development strategies while contributing to broader platform development and long-term protein sciences roadmap.

Collaborate across the company to achieve experimental and organizational goals, ensuring protein production aligns with project needs.

Identify and integrate state-of-the-art technologies to enhance capabilities and throughput of the Protein Sciences group.

Balance external (CRO) and internal resources to solve problems and drive progress.

Oversee biologics developability and collaborate on CMC efforts for advanced molecules.

Provide leadership and career development guidance to the team.

Present results and conclusions to the team, company, and at conferences.

Work closely with the Heads of Computational Biology and Discovery Biology in Boston, US, as well as antibody discovery leaders in Pilsen, CZ.

Report to the CSO and be a member of the Scientific Leadership team.

Required Qualifications

PhD in biochemistry, molecular or structural biology, or related disciplines with at least 10 years post-PhD research experience, including 5 years in biotech or large Pharma.

Expertise in antibody, bispecifics, and Fc fusion design, expression, and production, with a strong industry track record.

Hands-on expertise in biochemical, biophysical, and structural characterization of antibody therapeutics.

Experience managing antibody discovery and protein production at CROs.

Proven leadership, mentoring, and team-building skills.

Outstanding interpersonal and communication skills for cross-functional collaboration.

Highly motivated team player in a fast-paced, inclusive, ethical environment.

Preferred Qualifications

Experience with antibody design and discovery techniques such as immunization and display methods.

Experience progressing biologics to development candidates and clinical trials, including developability studies and CMC activities.

What We Will Offer You:

Comprehensive healthcare, dental, vision coverage, family leave, paid time off, 401k, disability, and life insurance, plus parking benefits.

A dynamic, early-stage, interdisciplinary, and collaborative work environment.

Opportunity to impact patient quality of life through targeted therapeutic development.

Professional growth through mentoring, cross-functional projects, and learning opportunities.

About Flagship Flagship Pioneering is a bioplatform innovation company creating platform companies with multiple products to transform health and sustainability. Since 2000, Flagship has originated over 100 ventures, with a combined value exceeding $90 billion. Many ventures address urgent challenges like COVID-19 vaccination, disease cures, health improvement, and sustainable agriculture. Recognized on Fortune’s “Change the World” list and Fast Company’s Most Innovative Companies, Flagship is committed to equal employment opportunity regardless of race, color, religion, sex, or other statuses.

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