About Stoke:

Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body's potential with RNA medicine. Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke's first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights

Stoke's initial focus for its TANGO platform is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency).

Stoke has identified STK-002 as a clinical candidate for the potential treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. The company is also pursuing a potential new medicine for Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals.

Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company's proprietary approach.

Position Purpose:

The Sr. Director, Medical Information will oversee the development and execution of the medical information strategy, ensuring the provision of accurate, balanced, and timely scientific and clinical information to healthcare professionals, patients, and internal stakeholders. This role will collaborate closely with Clinical Development, Medical Affairs, Advocacy, Regulatory, Pharmacovigilance, and other cross-functional teams to support product knowledge and ensure compliance with industry standards. This position reports into the Executive Director, Global Medical Communications.

Key Responsibilities: Lead the Medical Information function, ensuring the development of high-quality medical information responses and resources. Oversee the handling of medical inquiries from healthcare professionals, caregivers, patients, and internal teams, ensuring responses align with company policies and regulations. Develop and maintain medical information databases, standard response documents, and FAQs. Ensure compliance with industry regulations, including FDA, EMA, and other global health authorities. Collaborate with cross-functional teams to provide medical insights that inform product development, medical strategy, and commercial activities. Train internal stakeholders, including Medical Science Liaisons and Sales teams, on medical information policies and best practices. Monitor emerging scientific data and competitor activity to keep medical information materials up-to-date. Develop and implement key performance indicators (KPIs) to assess the effectiveness of medical information services. Represent the company in external medical information forums and industry meetings. Required Skills & Experience: Advanced degree (PharmD, MD, PhD, or equivalent) in a life sciences field. Minimum of 7-10 years of experience in Medical Information or related roles within the pharmaceutical or biotechnology industry. Strong knowledge of global regulatory guidelines governing medical information activities. Proven leadership experience with the ability to develop and manage high-performing teams. Excellent communication and presentation skills, with the ability to translate complex scientific data into understandable content for diverse audiences. Proficiency in medical literature evaluation and database management. Ability to work cross-functionally in a fast-paced, innovative environment. Experience with medical information systems and technology platforms is preferred.

Location(s):

Stoke operates sites in Bedford, MA. This position is hybrid/remote based position that will require a consistent presence with our office based staff.

Travel:

This position will require approximately ~10% travel, including occasional presence at internal meetings or conferences as required.

Culture & Values:

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual's needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging Committee (DIB) underscores the importance of DIB to who we are and what we do. Benefits & Compensation:

At Stoke Therapeutics we are proud to offer comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Parental Leave; a 401K program with company match, unlimited vacation time, and an Employee Stock Purchase Program (ESPP). Compensation is market competitive for the industry and directly commensurate with experience. All positions are bonus and stock eligible.

Interested candidates: Please visit Stoke's website to learn more and apply directly to the position listed on our Career Center.

For more information, visit stoketherapeutics.com or follow the company on X at @StokeTx.

All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.

Stoke participates in E-Verify.