Senior Director, Corporate Communications Bedford, Massachusetts, United States About Stoke: Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights Stoke’s initial focus for its TANGO platform is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Stoke has identified STK-002 as a clinical candidate for the potential treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. The company is also pursuing a potential new medicine for Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals. Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company’s proprietary approach. Position Purpose: The Senior Director of Corporate Communications will lead efforts to advance business strategy and performance through strategic, integrated communications. This individual will lead efforts to align and advance the corporate, product and commercial stories into a cohesive and compelling narrative as Stoke prepares to commercialize its first potential disease-modifying medicine and advances a pipeline of potential new medicines. This position reports to and works closely with the Chief Communications Officer and as a trusted advisor to business and executive leadership. This is a key role that is anticipated to provide continuing opportunities for growth and development as the company succeeds and is a leadership position that requires a dynamic, versatile, creative and experienced leader. The candidate must have deep experience in biotechnology or pharmaceutical communications, a broad understanding of the business and be someone who thrives in a fast-paced environment. This person must be motivated by the patient need and operate with utmost integrity. Core Responsibilities: Leads the development and implementation of an integrated strategic communications plan to advance Stoke’s corporate and product story and to build its reputation among key external stakeholders. Oversees the day-to-day activities of the communications function, including budgeting, planning, consultant/agency relationships and team development Serves as a trusted advisor to business leaders and executive leadership, including identifying opportunities and managing high-profile situations. Partners with cross-functional leadership to establish integrated communications strategies and plans to support business objectives, including data communications, corporate milestones, launch preparedness and issues management with Commercial, Medical, Clinical Development, Regulatory, Legal, Clinical Operations, Investor Relations, Advocacy and others. Serves as the primary point of contact for communications involving our collaborators. Leads efforts to increase Stoke’s visibility and reputation through media relations, thought leadership, web content, social media and strategic engagements. Builds and maintains relationships with journalists and influencers, pitching story ideas, managing inbound inquiries and serving as a spokesperson. Prepares Stoke executives for external speaking engagements and media interviews. Ensures compelling, consistent and effective messaging; leads the development of corporate communications materials including press releases, media materials, Q&A, slide decks, talking points, website content and videos. Works closely with the IR team on content for IR-related activities including quarterly business updates and investor events. Oversees corporate digital and social channels to ensure content is compelling, timely, accurate and effective from a technology and engagement standpoint. Supports the adaptation of corporate materials for use with other audiences including advocates, patients/caregivers, employees, clinicians, elected officials and others to ensure consistency in message. Analyzes and reports on learnings from communications/PR efforts and media coverage to drive effectiveness and continuous improvement. Studies and evaluates industry trends and peer activities to identify opportunities for Stoke to engage and improve, using experience and external benchmarks to make the case. Helps establish and codify best practices, policies and processes to meet the needs of the department and company. Required Skills & Experience: 10+ years of experience in public relations or communications in pharma/biotech, including product communications Proven success within and deep knowledge of pharma/biotech industry and regulatory environment Exceptional written and verbal communication skills Experienced in managing complex stakeholder relationships Established relationships with relevant media contacts as demonstrated through a track record of successful media relations and communications campaigns Strong cross-functional leader; able to influence at all levels and advocate for strategy, works collaboratively with colleagues and other stakeholders; actively solicits input and feedback; flexible and responsive Strategic thinker and problem-solver who is willing and able to implement tactically; is intellectually curious and perceptive Works well under pressure; has excellent time- and project-management skills and deep experience leading complex, time-critical projects; can manage multiple projects and thrive in a fast-paced, rapidly changing environment Can confidently and effectively advise and influence senior leaders on business strategy and key decisions Holds self and others to a high standard of ethics and integrity. Maintains confidentiality, exercises good judgment and discretion Effectively prioritizes workload, excellent organizational skills and attention to detail Location(s): Stoke is located in Bedford, MA. This position will work primarily on-site. Travel: This position will require approximately 15% travel for meetings. Culture & Values: At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation. Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging Committee (DIB) underscores the importance of DIB to who we are and what we do. Benefits & Compensation: At Stoke Therapeutics we are proud to offer comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Parental Leave; a 401K program with company match, unlimited vacation time, and an Employee Stock Purchase Program (ESPP). Compensation is market competitive for the industry and directly commensurate with experience. All positions are bonus and stock eligible. Interested candidates: Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center . All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status. Stoke participates in E-Verify. Apply for this job * indicates a required field First Name * Last Name * Email * Phone * Resume/CV * Enter manually Accepted file types: pdf, doc, docx, txt, rtf Enter manually Accepted file types: pdf, doc, docx, txt, rtf Education School * Select... Degree * Select... Select... Select... Start date year * End date month * Select... End date year * Please list any professional certifications you have * Address (Please include current City & State) * LinkedIn Profile Are you legally authorized to work in the U.S.? * Select... Will you now or in the future require sponsorship for employment visa status (e.g., H-1B visa) to legally work in the U.S.? * Select... Are you willing to travel for this role, if required? * Select... Attestation for Job Application * Select... I certify that I have read and understand the applicant instructions included with this application and that the answers given by me to the foregoing questions and statements made by me are complete and true to the best of my knowledge and belief.

I certify that I understand that Stoke Therapeutics participates in E-Verify and will provide the federal government with my Form I-9 information to confirm that I am authorized to work in the United States once I have accepted a job offer and completed the Form I-9.

I understand that any false information, omissions or misrepresentations of facts called for in this application, whether on this document or not, may result in rejection of my application or discharge at any time during my employment.

I understand that this application form is intended for use in evaluating my qualifications for employment and that this application is not an offer of employment. I further understand that if hired, my employment will be considered "at-will" and that my employment may be terminated for any reason, with or without cause or notice, at any time by me or the Company and that this application is not intended to constitute a contract of continued employment. Stoke is aware ofthepotential forrecruiting scams from individuals, organizations and internet sitesthatclaim to represent Stoke’s Human Resources team. Our company utilizes a formal interview process to identify candidates for open positions, and doesnotconduct interviews using third party websites, social media platforms, or through applications such as Telegram, WhatsApp or Flock. We also will never ask for money or fees at any point during the interview process. Current open positions can be viewed on our Job Opportunities page . Those who observe suspicious recruiting activity involving Stoke are encouraged to report it to info@stoketherapeutics.com as well as to the Internet Crime Complaint center at www.iC3.gov . External Recruiters Stoke does not accept unsolicited recruitment support from external parties. Candidates or resumes submitted to Stoke by external firms without a signed contractand/or without Stoke’s initiation for assistance with respective search will be deemed unsolicited in nature, and no fee will be paid in the event the candidate is hired.

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