Assistant, Associate, Or Full Member In Clinical Genomics

The Department of Pathology and Laboratory Medicine at Memorial Sloan Kettering Cancer Center (MSK) is seeking an outstanding faculty candidate at the level of Assistant, Associate, or Full Member to fill a position dedicated to development and clinical operationalization of next-generation sequencing (NGS) methods for cancer diagnosis and treatment selection. MSK is one of the world's premier cancer centers, committed to exceptional patient care and leading-edge research.

To enable large-scale tumor genomic characterization and facilitate enrollment to precision oncology clinical trials, we have implemented several innovative NGS-based assays as part of our world-leading clinical genomics program, including MSK-IMPACT for tumor tissue and MSK-ACCESS for circulating tumor DNA. MSK-IMPACT was the first tumor profiling test to be cleared by the US Food & Drug Administration and has been used as part of the clinical care of >100,000 MSK patients. MSK-ACCESS is approved by the NY State Department of Health and has been used for non-invasive liquid biopsy testing of >15,000 MSK patients. Newer tests for rapid genomic profiling and whole transcriptome RNA sequencing have also been approved and implemented. All clinical NGS testing is jointly operationalized by the Molecular Diagnostics Service and the Clinical Computational Diagnostics Service and performed by a collaborative team of pathologists, laboratory scientists, computational biologists, and administrative personnel.

Responsibilities include:

• Overseeing the clinical validation and implementation of NGS-based diagnostic tests within the Diagnostic Molecular Pathology Laboratory.
• Designing and developing new clinical tests to address emerging clinical needs in accordance with institutional strategic priorities.
• Serving as a technical resource to laboratory staff for experimental design, protocol development, and troubleshooting.
• Piloting novel technologies, processes, automation methods, and QA procedures across high-throughput nucleic acid extraction, sample preparation, and next-generation sequencing teams.
• Partnering with medical directors, bioinformatics teams, and departmental and service leadership to develop and execute MSK's clinical genomics strategy to support clinical research and patient care.
• Driving and sustaining a culture of continuous innovation and improvement.

Key qualifications include:

• A PhD or MD or equivalent degree.
• Expertise in next-generation sequencing technology, nucleic acid extraction, and high-throughput laboratory automation.
• Being a problem solver who can manage complex information to effectively solve problems in collaboration with diverse teams.

MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision.