General Summary: The Executive Director of Biostatistics is a strategic, dynamic, and empowered leader, overseeing statistical functions in support of multiple company therapeutic areas or portfolios. In addition, The incumbent is responsible for the methodological and quantitative scientific contributions of their group while simultaneously driving operational excellence. The Executive Director will have a highly visible and collaborative role, partnering across various R&D functions to generate evidence in support of Vertex pipelines/products. This position is based onsite at our Boston Seaport office. Relocation assistance is available. Key Duties and Responsibilities: Is responsible for leading/driving scientific statistical methodological expertise to impact the Vertex portfolio by application of both best in class and novel statistical approaches as part of unified Development strategies. This includes oversight of quantitative methods deployed across the portfolio with an eye towards efficiency and innovation. Serve as subject matter expert and owner when appropriate for key biometrics processes and associated operating model(s) related to Biostatistics SOPs, process maps, training and software/tools Own statistical support in the therapeutic areas and/or Global Medical Affairs he/she leads including early/late clinical developments, post-marketing studies, RWE studies and/or analyses supporting reimbursement Drive innovative trial designs in complex/fast changing environment to improve trial efficiency and shape the views of the executive team on important matters Serve as a key Leader on the Biostatistics Leadership Team to help set and drive vision and execution with respect to data operations, statistics, and statistical reporting/analytics. Represent Vertex externally, demonstrating scientific leadership and collaborating in industry, academic and regulatory forums as appropriate. Knowledge and Skills: Outstanding communication including clarity in writing including excellence in scientific/technical/process writing, influential speech and negotiation, ability to explain complex concepts to others, willingness and ability to engage in scientific discourse at the executive level. Demonstrated experience developing and leading high performing teams. Expert in statistical methodology including best practices and new industry trends. Agile learner and change agent. Executive presence and high degree of emotional intelligence Education and Experience: A Ph.D. in Statistics or Biostatistics 15+ years of relevant work experience or the equivalent combination of education and experience Pay Range: $252,000 - $378,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as:

Before applying for this role, please read the following information about this opportunity found below. 1. Hybrid : work remotely up to two days per week; or select 2. On-Site : work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

#J-18808-Ljbffr Remote working/work at home options are available for this role.