When was the last time you achieved the impossible? If that thought feels overwhelming, you might want to pause here, but if it sparks excitement…read on

In 2015, we pioneered a “moneyball for biotech” approach, pooling projects and promising early-stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allowsscience and small teams of experts to lead the way. We build bridges to groundbreaking advancements in rare disease, and develop life-changing medicines for patients with unmet needs as fast as humanly possible.

Together we define white space, push boundaries and empower people to solve problems. If you’re someone who defies convention, join us and work alongside some of the most respected minds in the industry. Together, we’ll ask “why not?” and help reengineer the future of biopharma.

Affiliate Overview

Calcilytix Therapeutics, an affiliate within BridgeBio Pharma, is developing encaleret, a negative allosteric modulator of the calcium-sensing receptor (CaSR) for the treatment of Autosomal Dominant Hypocalcemia Type 1 (ADH1), a genetic cause of hypoparathyroidism. Encaleret is currently being evaluated in a Phase 3 clinical study and has received Orphan Drug Designation from the US FDA, EMA, and PMDA as well as Fast Track Designation from the US FDA. Results from the Phase 2b clinical study of encaleret in patients in ADH1 were published in theNew England Journal of Medicine .

What You’ll Do

As the Director/Sr. Director, Business Development & Operations, you will play a key role in shaping the future direction of our Encaleret program. You will lead strategic planning efforts and provide critical insights that influence high-impact decisions. Your expertise will help guide commercial launch readiness, modeling & forecasting, preparation of corporate materials intended for presentation, corporate development, and strategic activities. You will also partner closely with cross-functional teams, including supply chain and operations, to ensure strategic alignment. Your analytical skills and industry experience will directly contribute to the company’s long-term success.

Responsibilities

Strategic Planning and Execution

• Shape and communicate the company’s strategic direction through well-structured presentations that guide prioritization and resource allocation
• Lead strategic analyses for program evaluation, including discounted cash flow modeling, and secondary research (e.g., analogs research, epidemiology, claims data analysis)
• Prepare a strategy to guide the successful US commercialization of encaleret

Stakeholder Communication

• Develop and deliver executive-level PowerPoint presentations that effectively communicate strategic insights, corporate initiatives, and market analyses
• Create high-quality visual materials for leadership offsites, Board of Directors meetings, investor discussions & communications, and internal alignment efforts
• Ensure presentations are tailored to the audience, synthesizing technical and business content into clear, concise, and actionable messaging
• Present and discuss findings of strategic analyses to a variety of audiences, including the Calcilytix team, leadership, and investors
• Support corporate development and partnering strategy to ensure that Encaleret can be accessed by patients worldwide

Supply Chain & Manufacturing Partnership

• Partner with Technical Operations and CMC teams to assess long-term supply chain capabilities and infrastructure needs
• Develop strategic analyses related to contract manufacturers (CMOs), raw material sourcing, and distribution logistics
• Contribute to make-vs-buy decisions, cost optimization, and supply chain resilience planning, especially as pipeline products move toward commercialization

Cross-functional Partnership

• Collaborate with R&D, Regulatory, Finance, Commercial, and Operations to ensure holistic strategy development
• Collaborate with functional experts as a strategic partner to support the clinical and commercial success of Encaleret
• Collaborate with the BridgeBio commercial team and oversee research in pricing and reimbursement
• Lead or contribute to special initiatives involving product lifecycle planning, global expansion, or operational efficiency

Where You’ll Work

This is a hybrid role and requires in-office collaboration at least 2-3x per week in our San Francisco or Palo Alto Office.

Who You Are

• A higher degree or equivalent, such as an M.B.A., M.D., or Ph.D., is preferred
• 2-5 years of professional experience in management consulting (life sciences preferred), post-Series A investing, investment banking, venture capital, equity research, and/or corporate role in a therapeutics company
• Prior experience contributing to new product commercialization is a plus
• Proven scientific acumen, communication skills, and an analytical mindset
• A passion for helping patients
• Proficiency in financial modeling, particularly DCF models
• Tenure-appropriate understanding of the drug development life science and operating model. Understands how value is created across the lifespan of a molecules from discovery to commercial execution
• Tenure-appropriate understanding of the biotech landscape
• exceptional written communication and presentation skills

Rewarding Those Who Make the Mission Possible

We have high expectations for our team members. We make sure those working hard for patients are rewarded and cared for in return.

• Market leading compensation
• 401K with 100% employer match on first 3% & 50% on the next 2%
• Employee stock purchase program
• Referral program with $2,500 award for hired referrals
• Comprehensive health care with 100% premiums covered – no cost to you and dependents
• Mental health support via Spring Health (6 therapy sessions & 6 coaching sessions)
• Hybrid work model – employees have the autonomy in where and how they do their work
• Unlimited flexible paid time off – take the time that you need
• Paid parental leave – 4 months for birthing parents & 2 months for non-birthing parents
• Flex spending accounts & company-provided group term life & disability
• Subsidized lunch via Forkable on days worked from our office

Skill Development & Career Paths:

• People are part of our growth and success story – from discovery to active drug trials and FDA pipelines, there are endless opportunities for skill development and internal mobility
• We provide career pathing through regular feedback, continuous education and professional development programs via LinkedIn Learning, LifeLabs, Spring Health & BetterUp Coaching
• We celebrate strong performance with financial rewards, peer-to-peer recognition, and growth opportunities