Overview Director, Translational Genetics role at GSK. Job Purpose We are seeking a highly experienced, motivated and innovative individual to join the Translational & Clinical Genetics team within the GSK Human Genetics and Genomics organisation. The successful candidate will provide strategic leadership and undertake hands-on analyses to identify, develop and deliver a portfolio of translational data-driven activities to impact the GSK portfolio. You will have strong expertise in genetics, with emphasis on causal inference approaches, and demonstrable experience of integrating genetics with genomics (especially proteomics) and clinical phenotypic data. Your work will inform target discovery, biomarker discovery, disease and mechanistic understanding, indication and patient subgroup selection, and parsing treatment response using precision medicine approaches. The successful candidate will lead a team of direct reports and work in a multidisciplinary, collaborative environment, interacting with GSK scientists and leaders from a range of functions and external collaborators to advance drug discovery and clinical development. You will have opportunities to establish collaborations with external institutions aligned with strategic priorities and to develop scientific leadership through impactful work, presentations, and peer-reviewed publications. Key responsibilities Utilize deep expertise in statistical genetics and the integration of genetics with genomic (including proteomics) and clinical phenotypic data to generate at-scale insights and address targeted translational scientific questions. Provide strategic leadership and hands-on analytical work to identify, develop, and deliver programs of work to impact the GSK drug development pipeline. Work within and lead cross-functional GSK project teams, with focus on respiratory, hepatology, neurodegeneration, immunology and/or renal disease. Identify, set up and oversee external scientific collaborations. Communicate analysis findings with expert interpretation to project teams within and outside the GSK Human Genetics & Genomics organisation. Deliver personal and team deliverables against objectives, applying strong statistical, analytic and translational context. Stay informed about emerging technologies and causal inference methodologies, evaluating their potential for implementation in the organization. Lead a team of direct reports and foster a culture of innovation, collaboration, and continuous professional learning. Basic Qualifications PhD or equivalent advanced degree in a relevant scientific discipline (e.g. statistical genetics, genetic epidemiology, biomedical statistics, computational sciences, bioinformatics or machine learning) with a history of impactful scientific publications and/or presentations. Extensive experience in genetics and analyses that integrate genetics, genomics (proteomics) and clinical phenotypic data to address translational questions in drug discovery and development. Expertise in genetic causal inference approaches (Mendelian randomization) with understanding of emerging methodologies. Ability to develop and implement new methodologies to integrate genetics and genomics for translational questions in drug discovery and development. Demonstrated ability to understand scientific questions and develop innovative analytical solutions to impact the drug discovery pipeline. Strong proficiency in R or Python, with reproducible and scalable code adhering to FAIR principles. Experience in line management and supporting professional development of team members. Demonstrated ability to communicate complex scientific concepts to diverse audiences. Preferred Qualifications Excellent collaboration and partnership skills to work with internal stakeholders across functions. Experience setting up and overseeing external collaborations. Experience in trusted research environments (TREs). Ability to work independently and in multidisciplinary teams to meet project timelines. Familiarity with stages of drug discovery and development. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company focused on four therapeutic areas and committed to an agile working culture. We are an Equal Opportunity Employer and provide adjustments to support applicants where needed. For adjustments, contact UKRecruitment.Adjustments@gsk.com or 0808 234 4391. Our UK Recruitment FAQ guide is available for common questions. Additional information Seniority level: Not Applicable Employment type: Full-time Job function: Other Industries: Pharmaceutical Manufacturing

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