Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! DIRECTOR, GLOBAL PRODUCT STRATEGY & OPERATIONS SUMMARY: The Director, Global Product Strategy & Operations will work closely with the Chief Global Product Strategy Officer and the Commercial, Medical Leadership Team (CMLT) to define and drive key strategic and process initiatives, ensuring efficiency and excellence in the Global Product Strategy & Operations (GPSO) team and the broader Ionis organization. RESPONSIBILITIES: Executional excellence and transformation Develop ambitious and challenging department objectives driving towards the vision for GPSO established by the Chief Global Product Strategy Officer Define and track KPIs and cross-functional dependencies, proactively identify risks and partner cross-functionally to mitigate issues for timely execution Lead key cross-functional GPSO business transformation initiatives, and represent GPSO in Ionis wide initiatives, ensuring effective integration of people / process / technologies Serve as an unbiased strategic thought partner to the Chief Global Product Strategy Officer; maintain an objective perspective on high-priority decisions, represent different sides of the same, complex issue and develop alternative solutions

Budget strategy & management Lead the annual GPSO budgeting process in strong collaboration with Finance peers Source benchmarks to validate individual project thinking; maintain a broad view of cross-functional operations, identifying opportunities for synergy and savings Pressure test the GPSO operating model, advise the Chief Global Product Strategy Officer on resource allocation / optimization opportunities and appropriate gating Track cross-functional Budget performance and decision gates across the year to unlock investments at the right time and place Lead quarterly forecasting, and identifying opportunities for improvement

Board engagement Partner with CMLT and executive team to ensure effective engagement with Board to guide and advise on GPSO priorities, deliverables, and strategy Facilitate execution of quarterly GPSO Board material development, ensuring an aligned voice is represented in cross-functional deliverables Deliver on agreed follow-up requests and commitments

Proactive, strategic communications Partner with Communications team to develop, refine, and execute strategic communication plans, for internal and external audiences, aligned with GPSO priorities Accelerate change management and ensure alignment with Ionis messaging. Offer strategic insights into key themes and messaging based on business context Represent GPSO perspective in cross-functional meetings, communicating key points effectively to key stakeholders within GPSO, Ionis leadership, as well as to key external partners and customers

Process and decision optimization Drive a strategic agenda for CMLT bi-weekly meetings, and ensure cross-GPSO topics, including strategy, process, and culture, are curated on an appropriate cadence Lead planning and delivery of in-person and virtual GPSO all hands meetings Ensure appropriate cascade of relevant information and decisions to key stakeholders and GPSO team members Drive accountability for decisions and assigned action items, tracking initiatives according to plans, identify potential risks/mitigations, and supporting completion

Other responsibilities as assigned REQUIREMENTS: Bachelor's degree and a minimum of 15 years of related experience Advanced degree preferred with at least 12 years of related experience

Strong record of achievement working in a broad operations role and partnering with C-level executives and other cross-functional leaders Biotechnology experience strongly preferred High degree of autonomy, proactivity, leadership, and self-motivation, demonstrating initiative and an ability to self-identify and manage multiple priorities with a sense of urgency and results orientation, with minimal oversight Prior experience working with Boards of Directors is important Ideally will have helped an organization go through a growth-oriented transformation Strong business judgment, influence skills, leadership, and integrity are essential High degree of intellectual agility to handle complex business and technical issues Natural curiosity, superior critical thinking skills, and passion for learning Strong long- and short-term planning skills Demonstrated, strong people leadership experience Possess sound judgment combined with solid relationship development skills, effectively interfacing with all levels of the organization Highly effective in formulating coordinated and well-communicated action plans and activities Superior time and project management, organizational skills, and attention to detail; ability to manage a varied-in-subject but high capacity of work Strong oral and written communication skills Able to effectively navigate organizational complexity, understanding the interdependencies and evolving priorities High "EQ" and collaborative, with a spirit of generosity to help others Open and honest Demonstrated ability to develop strong, trusting business relationships at all levels and be regarded as a trusted partner Strong facilitation, diplomacy, negotiation, and mediation These business and professional attributes will be complemented with superior emotional and intellectual acuity required to facilitate communications with the Executive Leadership Team members, and company leadership across multiple functions Please visit our website, http://www.ionispharma.com for more information about Ionis and to apply for this position; reference requisition # IONIS003820 Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits Full Benefits Link: https://www.ionispharma.com/careers/working-at-ionis/#:~:text=our employee spotlight-,Benefits,-Employees are rewarded The pay scale for this position is $185,000 to $210,000 NO PHONE CALLS PLEASE. PRINCIPALS ONLY. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers. Equal Opportunity Employer

Apply below after reading through all the details and supporting information regarding this job opportunity. This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.

#J-18808-Ljbffr