Join to apply for the Director, Drug Metabolism (Biotransformation) role at Gilead Sciences 2 hours ago Be among the first 25 applicants Join to apply for the Director, Drug Metabolism (Biotransformation) role at Gilead Sciences At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.

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Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.

Job Description

The primary responsibility of this position is to lead biotransformation activities in the Drug Metabolism Department and in collaboration with the Clinical group. The scientist will be the subject matter expert and provide strategy/guidance to project teams for advancement of candidate compounds. This job role will focus on metabolite profiling and characterization of those compounds in vitro and in vivo to understand metabolic pathways to support drug discovery and development. More broadly, the scientist is expected to integrate this information with absorption, distribution and excretion data for candidate compounds for a full understanding of their drug metabolism and pharmacokinetic (PK) behavior. This will include representation of the department on multidisciplinary project teams. Supervision and mentoring of other scientists and/or laboratory staff will be required. This role will be based in our headquarters in Foster City, CA.

Essential Duties And Job Responsibilities

Work closely with internal and external resources to assure high quality and timely delivery of nonclinical and clinical biotransformation data for molecules in discovery and development, including 14C mass balance studies. Design and perform complex analyses to characterize biotransformation and disposition of candidate drugs. Serve as a drug metabolism and biotransformation subject matter expert for multiple dynamic cross-functional teams, to define strategies to achieve target product profiles, integrate in vitro and in vivo drug disposition data, interpretation, and give presentations to teams. Provide clear verbal communication of results and strategies at group, department, project team and management level. Write research reports and regulatory documents. Contribute to science through conference presentations and publication of new findings.

Basic Qualifications

Bachelor's Degree and Twelve Years’ Experience

OR

Masters' Degree and Ten Years’ Experience

OR

PhD and Eight Years’ Experience

Preferred Qualifications

A highly motivated individual with PhD degree in life sciences with 8 - 10 years of post-doctoral and/or industry experience directly related to the Specific Responsibilities listed above (hands-on experience and deep knowledge of biotransformation and structure elucidation). Considered an expert in metabolic routes of biotransformation and metabolite identification demonstrated through presentation/publication. Comfortable working with and educating colleagues in drug metabolism, toxicology and clinical pharmacology departments, on strategies to understand drug metabolism and disposition. Demonstrates excellent scientific verbal and technical communication, and interpersonal skills. Must be organized, pay attention to details and have strong organizational and planning skills. Expertise and experience in one or more of the following areas: Lead design and execution of nonclinical and clinical radio- and non-radiolabeled ADME studies. Serve as an expert resource; to ensure radiochemical design, develop protocols and placement of studies. Provide oversight and integration of the data and data reports. Proactively manage resolution of data gaps. Ensure reports are written to communicate clear messages and are ready for regulatory submissions. State of the art bioanalysis by LC/MS, F-NMR and related techniques

People Leader Accountabilities

Create Inclusion - knowing the business value of diverse teams, modeling inclusion, and embedding the value of diversity in the way they manage their teams. Develop Talent - understand the skills, experience, aspirations, and potential of their employees and coach them on current performance and future potential. They ensure employees are receiving the feedback and insight needed to grow, develop, and realize their purpose. Empower Teams - connect the team to the organization by aligning goals, purpose, and organizational objectives and holding them to account. They provide the support needed to remove barriers and connect their team to the broader ecosystem.

The salary range for this position is: $226,185.00 - $292,710.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

For Additional Benefits Information, Visit

https://www.gilead.com/careers/compensation-benefits-and-wellbeing

Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

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Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance.

For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster.

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Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Gilead Employees And Contractors

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