Well-funded biotech in SSF seeks a Computational Chemistry Director or Associate Director with experience in CADD- and structure-based design for lead optimization of small molecules to advance the pipeline of innovative therapeutics toward the clinic.

Do you have the following skills, experience and drive to succeed in this role Find out below.

**Onsite in South San Francisco Monday through Friday (5 days/week)**

Highlights : Reports to SVP, Discovery Potential to have one or more direct reports Two lead targets: CNS oncology + neurodegeneration Financial runway forecasted through Spring 2027 ~25 full-time employees

Responsibilities : Provide strategic leadership and hands-on execution of our CADD efforts Collaborate closely with chemists and biologists on virtual screening, hit identification and structure-based design Guide the optimization of drug candidates that induce protein degradation Use machine-learning (ML) to build in silica models to predict DMPK properties Perform and automate high throughput molecular dynamics simulations to predict protein function and protein-ligand binding Utilize established tools and design new methods/tools Scientific programming as needed

Required Qualifications: PhD in Computational Chemistry or related discipline 7+ years of relevant experience in drug discovery Computer aided drug design (CADD) /structure- and ligand-based design for small molecules Dotmatics, Schrodinger, MOE, OpenEye, or Gaussian software QSAR, QSPR, and conformational analysis Molecular mechanics and dynamics simulations

Preferred Skills & Knowledge: Understanding of in vitro and in vivo DMPK principles Artificial Intelligence/Machine Learning (AI/ML) approaches to predictive modeling Quantum mechanics methods Statistical design of experiments (DoE) Multiparameter optimization Experimental assay methods and technology for protein-ligand interactions Programming with languages such as perl, python, or C++ Cheminformatics / database algorithms Emerging drug modalities such as covalent inhibitors, bifunctionals, molecular glues and/or PROTACs