Overview The Senior Director, US Payer Medical Affairs & Outcomes Strategy will report to the Vice President of US Medical Affairs, TTR and will have dual accountability across two core domains: Medical Director Leadership (50%) - Lead the design and execution of the US Payer Ecosystem Medical Plan, including real-world evidence (RWE) strategy and collaborative pilots with payer organizations. Partner with internal and external stakeholders to generate meaningful insights that support patient access, value demonstration, and differentiation of Alnylam's portfolio. Field Team Leadership (50%) - Oversee the US Payer Medical Outcomes Science Liaisons (MOSLs), ensuring strategic alignment and flawless execution of payer-focused initiatives. Provide coaching, mentoring, and performance management to optimize team impact across the managed care landscape. This position is a US-Field based position. Key Responsibilities US Payer Medical Director Accountabilities (50%) * Lead the US Payer Ecosystem Medical Plan in alignment with brand, evidence generation, and access strategies. * Develop and implement a real-world payer evidence strategy that includes payer-driven research collaborations, pragmatic pilots, and data partnerships to address evidence needs for access and reimbursement. * Serve as the primary scientific and clinical point of contact for US payer stakeholders, including PBMs, MCOs, IDNs, and state Medicaid programs. * Collaborate with Health Economics & Outcomes Research (HEOR), Value & Access, and Policy teams to ensure payer evidence needs are incorporated into US and global evidence plans. * Shape and lead strategic payer-focused research collaborations , ensuring alignment with both scientific rigor and payer decision-making needs. * Act as a thought leader in payer-focused evidence generation , representing Alnylam in external forums and advancing partnerships with US healthcare systems. US Payer MOSL Team Leadership (50%) * Lead and manage theUS Payer MOSL organization, ensuring execution of strategy with excellence and consistency across regions. * Translate payer evidence needs into actionableMOSL field engagement strategies, aligning account planning with corporate medical objectives. * Providecoaching, development, and performance oversightfor MOSLs, fostering a culture of accountability, collaboration, and innovation. * Partner closely with National Accounts, Market Access, and US Medical leadership to deliver an integrated field medical strategy across payer segments. * Ensure strict compliance with all applicable PhRMA Codes, FDA laws, regulations, and company policies. * Champion cross-functional collaboration to align payer field activities with corporate priorities and ensure seamless execution. Qualifications * 10+ years of experience inMedical Affairs, HEOR, or payer-focused functions within biopharma/healthcare. *Required:Experienceeither at a US payer organization(e.g., MCO, PBM, Medicaid/Medicare, IDN)or within the pharmaceutical/biotech industry leading US payer medical and evidence strategy. * Advanced degree in life sciences (MD, DO, PharmD, PhD) strongly preferred. * Proven experience developing and executingpayer medical strategiesandreal-world evidence initiatives. * Deep understanding of theUS payer landscape, including policy, access drivers, and evidence requirements. * Demonstrated leadership experience managing field medical teams or payer-facing medical organizations. * Excellent scientific communication skills with ability to engage credibly with payer medical directors, pharmacy directors, and value committees. * Strong organizational and strategic planning skills, with a track record ofleading cross-functional initiatives. * Ability to travel up to 50%. U.S. Pay Range $240,600.00 - $325,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer. >