Job Title: Regional Medical Science Director Department: Medical Affairs Location: Remote US About Summit: Ivonescimab, known as SMT112, is a novel, potential first-in-class investigational bispecific antibody combining the effects of immunotherapy via a blockade of PD-1 with the anti-angiogenesis effects associated with blocking VEGF into a single molecule. Ivonescimab displays unique cooperative binding to each of its intended targets with multifold higher affinity when in the presence of both PD-1 and VEGF. Summit has begun its clinical development of ivonescimab in non-small cell lung cancer (NSCLC), with three active Phase III trials: HARMONi is a Phase III clinical trial which intends to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR-mutated, locally advanced or metastatic non-squamous NSCLC who have progressed after treatment with a 3rd generation EGFR TKI (e.g., osimertinib). HARMONi-3 is a Phase III clinical trial which is designed to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first-line metastatic NSCLC. HARMONi-7 is a Phase III clinical trial which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first-line metastatic NSCLC whose tumors have high PD-L1 expression. Ivonescimab is an investigational therapy that is not approved by any regulatory authority in Summit’s license territories, including the United States and Europe. Ivonescimab was approved for marketing authorization in China in May 2024. Ivonescimab was granted Fast Track designation by the US Food & Drug Administration (FDA) for the HARMONi clinical trial setting. Overview of Role: The Regional Medical Science Director (also referred to as MSL) is a field based scientific expert that strategically supports the scientific and business objectives of cancer therapeutic areas across the product life cycle. MSLs are the primary communicators of Summit Therapeutics science within a specific geography with healthcare professionals. MSLs are the field scientific experts on Immuno-Oncology and treatment options within this therapeutic area. They combine strong business acumen, clinical expertise, market awareness, and serve as a conduit of information to a cross functional customer base internally within Summit Therapeutics. Based on therapeutic needs and product life cycles, teams may focus on certain responsibilities, including clinical development and pipeline support. Role and Responsibilities: Develop, execute and maintain high impact territory plans, including HCP and Investigator engagement plans in alignment with therapeutic area medical and scientific objectives with a focus on quality Support clinical development and research initiatives across development at the request of R&D to include, but not limited to, site evaluation and identification, recruitment, investigator meetings, external expert identification, and involving experts to generate scientific data including investigator-sponsored trials Identify, gain access to, and develop professional customer centric based relationships with external experts in Immuno-Oncology within assigned geography Provide education relative to disease state, therapeutic landscape and Summit Therapeutics products across the product lifecycle to healthcare providers and researchers Participate, monitor, and provide insights to Summit from relevant scientific meetings in relevant geography Continuously maintain self-education on market issues/trends, product knowledge, and new therapeutic areas of interest as it pertains to specific business responsibilities, including creating awareness and relationships for Summit Therapeutics in the Medical community Actively participate in relevant team meetings, organizational activities, and Country-driven medical affairs activities (e.g. advisory boards, masterclasses, roundtables) Create, maintain, and collaborate in relationships with Cross-Functional partnerships, as appropriate, to develop and execute Account plans designed to support and meet shared scientific or business objectives All other duties as assigned Experience, Education and Specialized Knowledge and Skills: Doctoral degree in the health sciences from an accredited university required (MD, PhD, PharmD, or equivalent). Significant clinical and/or industry experience in oncology and cancer therapeutic area may be accepted in lieu of education requirements. A minimum of 5+ years of solid tumor cancer experience A minimum of 5+ years of clinical, scientific/research, or industry related experience or equivalent A minimum of 2+ years’ experience in Medical Science Liaison role Previous pharmaceutical industry experience within relevant scientific discipline is strongly preferred The MSL must possess and be able to demonstrate past achievements in: Understanding, analyzing and communicating complicated scientific concepts and data Building credible relationships with prominent HCPs Ability to independently identify and translate corporate needs into an action plan that will achieve objectives Self-motivation to achieve and exceed goals Problem solving and analytic skills Critical thinking Ability to work independently

An essential requirement of the position is to meet health care industry representative (HCIR) credentialing requirements to gain entry into facilities and organizations that in your assigned territory. These HCIR credentialing requirements may include, but are not limited to, background checks, drug screens, and proof of immunization/vaccination for various diseases. Other requirements: Must be willing to travel up to 75% of the time Proficient user of standard MS Office suite (e.g., Word, Excel), experience using electronic document management systems, and document review tools desirable Strong computer and database skills Attention to detail, accuracy and confidentiality Clear and concise oral and written communication skills Excellent organizational skills Must be able to effectively multi-task and manage time-sensitive and highly confidential documents Prioritize conflicting demands Work in a fast-paced, demanding and collaborative environment

The pay range for this role is $200,000-$235,000 annually. Actual compensation packages are based on several factors that are unique to each candidate, including but not limited to skill set, depth of experience, certifications, and specific work location. This may be different in other locations due to differences in the cost of labor. The total compensation package for this position may also include bonus, stock, benefits and/or other applicable variable compensation. Summit does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact Summit’s Talent Acquisition team atrecruiting@smmttx.comto obtain prior written authorization before referring any candidates to Summit.

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