Executive Director/Vice President, Commercial Operations Bedford, Massachusetts, United States; Hybrid About Stoke: Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights Stoke’s initial focus for its TANGO platform is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Stoke has identified STK-002 as a clinical candidate for the potential treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. The company is also pursuing a potential new medicine for Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals. Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company’s proprietary approach. Key Responsibilities: Executive Director/VP, Commercial Operations works cross-functionally to identify and implement best practices, methodologies and processes to achieve commercial and operational excellence. This role will be responsible for the operational build, development and maintenance of commercial systems, forecasting, market research, field data support, policies and governance documents to support both the launch and commercialization of Stoke’s products. This will include planning for weekly performance reports and insights at launch. The role will also be responsible for field force incentive compensation, working closely with field leadership in Sales and Market Access. Additionally, in partnership with IT, they will identify, develop and deploy enterprise functions and platform technology solutions to maximize operational effectiveness, and work closely with third party vendors such as CRM providers and data aggregators. Work closely within Commercial and Finance to build, analyze and communicate Commercial program budgets to ensure accurate forecasting reporting. Responsible for developing and reporting daily/weekly revenue process with Finance at launch. Collaborate with Finance and Manufacturing to develop and support the monthly/quarterly revenue forecasting process. Collaborate with Commercial stakeholders to coordinate and synergize all market research needs and efforts. Work with cross-functional team members to identify and prioritize actionable, high-impact insights across a variety of core business areas including Sales, Medical Affairs, Marketing, Finance, Market Access, Patient Services and IT. Research, design, implement, and validate cutting-edge dashboards to analyze diverse sources of data to achieve targeted outcomes. Institute processes for data and reporting governance of ad-hoc field-based inquiries from the Executive Leadership Team and other Commercial functions. Design, develop, implement and lead the company's data warehouse with input from Commercial, IT, Quality and Finance. Strategic and tactical planning for field teams including management of vehicle allowance, incentive compensation design and administration, data management, reporting, and CRM management. Lead data inquiry and data stewardship efforts in support of field-based teams Collaborate with IT to develop Stoke’s enterprise data strategy Any and all other responsibilities as requested Required Skills & Experience: A minimum of 10 years of pharmaceutical/biotech industry experience. Bachelor’s degree or equivalent experience in Commercial Operations, Business Intelligence, Data Management or Analytics. Good verbal and written communication with solid organizational, time management, and project management skills. Strong personal leadership skills to drive performance and support corporate objectives. Ability to work collaboratively and effectively with others. Ability to work under pressure and meet deadlines. Strong analytical and communication skills. Well organized and detail oriented. Creativity and resilience in problem solving. Relentless hands-on drive to implement and accomplish performance goals. Effective management of vendor partners to ensure project scope is achieved within defined budget. Ability to independently research, design, and implement platform technology solutions. Location(s): Stoke is located in Bedford, MA. This position is a hybrid with an office setting based in Bedford, MA location. Travel: This position will require approximately 5% travel. Culture & Values: At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation. Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging Committee (DIB) underscores the importance of DIB to who we are and what we do. Benefits & Compensation: At Stoke Therapeutics we are proud to offer comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Parental Leave; a 401K program with company match, unlimited vacation time, and an Employee Stock Purchase Program (ESPP). Compensation is market competitive for the industry and directly commensurate with experience. All positions are bonus and stock eligible. Interested candidates: Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center . All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status. Stoke participates in E-Verify. Create a Job Alert Interested in building your career at Stoke Therapeutics? Get future opportunities sent straight to your email. Accepted file types: pdf, doc, docx, txt, rtf Enter manually Accepted file types: pdf, doc, docx, txt, rtf Education School * Select... Degree * Select... Select... Select... Start date year * End date month * Select... End date year * Please list any professional certifications you have * Address (Please include current City & State) * LinkedIn Profile Are you legally authorized to work in the U.S.? * Select... Will you now or in the future require sponsorship for employment visa status (e.g., H-1B visa) to legally work in the U.S.? * Select... Are you willing to travel for this role, if required? * Select... Attestation for Job Application * Select... I certify that I have read and understand the applicant instructions included with this application and that the answers given by me to the foregoing questions and statements made by me are complete and true to the best of my knowledge and belief.

You can get further details about the nature of this opening, and what is expected from applicants, by reading the below. I certify that I understand that Stoke Therapeutics participates in E-Verify and will provide the federal government with my Form I-9 information to confirm that I am authorized to work in the United States once I have accepted a job offer and completed the Form I-9.

I understand that any false information, omissions or misrepresentations of facts called for in this application, whether on this document or not, may result in rejection of my application or discharge at any time during my employment.

I understand that this application form is intended for use in evaluating my qualifications for employment and that this application is not an offer of employment. I further understand that if hired, my employment will be considered "at-will" and that my employment may be terminated for any reason, with or without cause or notice, at any time by me or the Company and that this application is not intended to constitute a contract of continued employment. Stoke is aware ofthepotential forrecruiting scams from individuals, organizations and internet sitesthatclaim to represent Stoke’s Human Resources team. Our company utilizes a formal interview process to identify candidates for open positions, and doesnotconduct interviews using third party websites, social media platforms, or through applications such as Telegram, WhatsApp or Flock. We also will never ask for money or fees at any point during the interview process. Current open positions can be viewed on our Job Opportunities page . Those who observe suspicious recruiting activity involving Stoke are encouraged to report it to info@stoketherapeutics.com as well as to the Internet Crime Complaint center at www.iC3.gov . External Recruiters Stoke does not accept unsolicited recruitment support from external parties. Candidates or resumes submitted to Stoke by external firms without a signed contractand/or without Stoke’s initiation for assistance with respective search will be deemed unsolicited in nature, and no fee will be paid in the event the candidate is hired.

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