Overview The Director of Supply Chain Planning is responsible for end-to-end inventory and production planning across Dyne’s external supply network. This includes long-range planning (LRP), ensuring uninterrupted clinical supply, and supporting commercial launch readiness through scenario-based planning and risk assessments. This strategic role is critical in executing current planning activities and shaping future supply chain capabilities. The Director collaborates cross-functionally with Process Development, Research, CMC, Quality, Clinical Operations, and Commercial teams. It is an opportunity to help shape the future of Dyne’s supply chain function during a critical period of growth and innovation.

This role is based in Waltham, MA with no possibility for fully remote work.

About Dyne Therapeutics Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook.

Responsibilities

Collaborate with cross-functional partners in CMC, Logistics, Quality, Clinical Operations, and Commercial to develop and maintain a reliable demand and supply plan, ensure uninterrupted product availability for patients, support commercial readiness, and align with the company’s business objectives.

Maintain an understanding of external manufacturing site capacities, capabilities, and supply risks.

Identify and implement opportunities to optimize supply chain processes and drive efficiencies.

Lead scenario planning to evaluate alternative demand and supply assumptions and inform risk mitigation strategies.

Lead monthly demand and supply planning meetings with cross-functional team members as part of our drive to a formal Integrated Business Planning / Sales and Operations Planning process.

Perform analysis of Dyne portfolio, including inventory projections, supply performance and risks.

Integrate with other global planning processes to monitor key performance indicators (KPIs) and analyze supply chain data to identify opportunities for improvement and cost savings.

Author supply chain-related standard operating procedures (SOPs) and work instructions.

Manage relationships with third-party suppliers and vendors to ensure timely delivery of materials and components.

Ensure compliance with regulatory requirements and quality standards in supply chain operations.

Qualifications

Bachelor’s degree in Supply Chain, Business, Engineering, or a related field; advanced degree preferred. Minimum of 10 years of relevant experience in a biotech, pharmaceutical, or life sciences environment.

Ability to effectively plan, prioritize, execute, follow up and anticipate challenges.

Experience managing complex schedules and priorities in dynamic pharmaceutical, biotech or related environments.

Ability to work, influence, and gain agreement across multiple functions.

Strong analytical, problem solving and critical thinking skills.

Strong knowledge of supply chain best practices, inventory management, and demand forecasting.

Proficiency in advanced Excel functions and familiarity with planning and analytics tools such as Smartsheet, Visio, ERP systems (e.g., SAP, Oracle), and Power BI.

Collaborative work style to be part of a team to identify process gaps and develop solutions.

Excellent interpersonal, verbal, and written communication skills.

Experience in supply chain, drug development, project management, and/or pharmaceutical manufacturing/packaging.

In-depth working knowledge of regulations relating to clinical manufacturing, packaging and distribution activities (CGMP, GCP).

APICS or CSCMP certification a plus.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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