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Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Job Summary The Gene and Cell Therapy Institute (GCTI) is a newly created system-wide Institute under Mass General Brigham. The Institute will foster a world-class gene and cell therapy program that will leverage ongoing, groundbreaking scientific research efforts across the MGB system.

The mission of GCTI is to bring together the community of MGB investigators which can utilize gene and cell therapy platforms to achieve their scientific and clinical goals and improve the health of patients. The Institute will differentiate itself by harnessing the exceptional strengths of clinician scientists, the large and unique patient population, and major discoveries throughout the hospital system to propel MGB as the leader in Gene & Cell therapies.

The Director of mRNA-LNP Genetic Medicine will lead a cross-functional team in developing next-generation mRNA delivery platforms and coordinate translational efforts across academic and clinical stakeholders. We seek an innovative and collaborative scientist whose research focuses on the design, development, and clinical translation of messenger RNA (mRNA) therapeutics delivered via lipid nanoparticles (LNPs) for the treatment of genetic diseases, cancer, or infectious diseases.

The ideal candidate will establish a vigorous, externally funded research program, contribute to graduate and medical education, and foster cross-disciplinary collaborations. The candidate will also work closely with MGB investigators to identify GCT-related RNA therapeutic assets for further testing and development. The individual will report to the Head of Research at GCTI.

PRINCIPAL DUTIES AND RESPONSIBILITIES:

Faculty Role: • Establish and maintain a high-impact, externally funded research program. • Publish in leading peer-reviewed journals and present at national and international conferences. • Mentor graduate students, postdoctoral fellows, and junior researchers. • Teach in undergraduate, graduate, or professional programs as assigned.

Director Role: • Lead strategic research and development initiatives in mRNA-LNP delivery systems. • Oversee a core facility or translational unit focused on formulation, optimization, and preclinical testing of mRNA-based therapies. • Serve as a liaison between basic science, clinical, and industry collaborators. • Pursue translational partnerships and funding opportunities (e.g., NIH, DARPA, BARDA, biotech industry).

Qualifications

Required:

Ph.D., M.D., or M.D./Ph.D. in bioengineering, molecular biology, pharmacology, or a related field. Strong record of research productivity and publication in relevant areas (e.g., RNA therapeutics, nanomedicine, gene therapy). Experience with LNP design, formulation, and in vivo delivery techniques. At least 3-5 years of leadership and management experiences at leading discovery teams required At least 5-7 years of experience in strategies for targeting therapeutic agents to specific tissues or cells, such as lipid nanoparticle delivery, etc. required Preferred: Postdoctoral or industry experience in mRNA therapeutic development. Track record of securing extramural funding. Demonstrated leadership in cross-disciplinary or translational projects. Familiarity with regulatory and manufacturing considerations in genetic medicine. Additional Job Details (if applicable)

Working Conditions This is an onsite position

Remote Type

Onsite

Work Location

65 Landsdowne Street

Scheduled Weekly Hours

40

Employee Type

Regular

Work Shift

Day (United States of America)

Pay Range $96,907.20 - $158,100.80/Annual

Grade 9

At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package.

EEO Statement:

Mass General Brigham Incorporated is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

Mass General Brigham Competency Framework

At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.