Overview Rezolute is a late-stage rare disease company focused on significantly improving outcomes for individuals with hypoglycemia caused by hyperinsulinism (HI). Our antibody therapy, RZ358 (ersodetug), is designed to treat all forms of HI and has shown substantial benefit in clinical trials and real-world use for the treatment of congenital hyperinsulinism (cHI) and tumor hyperinsulinism (tumorHI). Director, Human Resources We are seeking a Director, Human Resources who will lead and execute key people strategies while serving as a trusted advisor and business partner to senior leaders within the organization. This role blends strategic HR business partnering with core HR responsibilities to drive a high-performance culture, employee engagement, and talent development. The ideal candidate will be an influential leader who can operate at both the strategic and operational levels. Key Responsibilities Strategic HR Business Partnering Serve as a strategic advisor to functional leaders, aligning HR initiatives with business goals. Partner closely with leadership to drive organizational effectiveness, talent strategy, workforce planning, and change management efforts. Guide leaders in performance management, coaching, succession planning, and employee relations matters. Employee Engagement & Culture Lead initiatives to build and sustain a positive, inclusive, and high-performance culture. Develop and implement employee engagement surveys and action plans. Promote programs that foster recognition, morale, and employee satisfaction. Employee Development, Reviews & Goal Setting Oversee the performance management cycle, including goal setting, feedback, and reviews. Partner with managers to build development plans and career pathing for employees. Support leadership in identifying high-potential talent and addressing development gaps. Compensation & Total Rewards Collaborate with leadership and external partners to manage compensation structures and total rewards programs. Provide guidance on salary benchmarking, merit cycles, promotions, and incentive programs. Ensure pay equity, transparency, and alignment with business objectives. Training, Development & Compliance Design and manage compliance and skills-based training programs across the organization. Ensure compliance with federal, state, and local employment laws, including training requirements. Lead onboarding and orientation processes to ensure a consistent and engaging new hire experience. Policy Development & HR Operations Maintain and update employee handbooks, HR policies, and standard operating procedures. Ensure consistency and compliance across all HR practices and employee relations. Partner with legal and compliance teams as needed to ensure best practices. Other Human Resource Responsibilities Collaborate closely with Talent Acquisition to drive headcount planning and deliver a best-in-class candidate and onboarding experience as the company scales. Support integration of new functions and capabilities (e.g., Commercial, Medical Affairs, Market Access) and associated change management initiatives. Provide day-to-day HR support to managers and employees, resolving employee relations issues with a proactive and empathetic approach. Use data and metrics to assess organizational health and drive continuous improvement in employee experience and engagement. Qualifications Bachelor’s degree in Human Resources, Business Administration, or related field; Master’s degree or HR certification (e.g., SHRM-SCP, SPHR) preferred. 10+ years of progressive HR experience, including 3+ years at a Director or senior HRBP level. Demonstrated success in a fast-paced, growing company (biotech/pharma industry preferred). Strong knowledge of U.S. employment laws and HR compliance. Proven ability to influence, coach, and build relationships with leaders at all levels. Excellent communication, organizational, and problem-solving skills. Comfortable working in both strategic and hands-on capacities. Rezolute (RZLT) currently anticipates the base salary for the Director of Human Resources role could range from $220,000 to $245,000 and will depend, in part, on the successful candidate’s geographical location and their qualifications for the role, including education and experience. This position will also be eligible for an annual performance bonus in accordance with the terms of the applicable plan (depending, in part, on company and individual performance and at the Company’s discretion on an individual basis). The compensation described above is subject to change and could be higher or lower than the range described based on current market survey data and the qualifications, education, experience and geographical location of the selected candidate. Rezolute offers competitive compensation, stock options and a rich benefits package. Qualifying employees are eligible to participate in benefit programs such as: - Health Insurance (Medical / Dental / Vision) - Disability, Life & Long-Term Care Insurance - Holiday Pay - Tracking Free Vacation Program - 401(k) Plan Match - Educational Assistance Benefit - Fitness Center Reimbursement We are an Equal Opportunity Employer and do not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class.

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